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Single-subject design or single-case research design is a research design most often used in applied fields of psychology, education, and human behavior in which the subject serves as his/her own control, rather than using another individual/group. Researchers use single-subject design because these designs are sensitive to individual organism differences versus group designs, which are sensitive to averages of groups. Often there will be large numbers of subjects in a research study using single-subject design, however—because the subject serves as their own control, this is still a single-subject design. These designs are used primarily to evaluate the effect of a variety of interventions in applied research. 

Improving Descriptions of Single-Subject Experiments in Research Texts Written for Undergraduates

Single Subject Designs powerpoint

Use of Single Subject Designs in Psychology